Direct and indirect allograft recognition

Direct and indirect antigen recognition: the pathways to allograft immune rejection.

The immune rejection of allografts is mediated by T cells via two distinct pathways: the direct and the indirect pathways. Direct alloresponse to intact donor MHC molecules is ensured by T cells which are polyclonal and directed toward a variety of antigens. This response is highly sensitive to treatment by immunosuppressive drugs including Cyclosporin A. Indirect alloresponse is oligoclonal an...

Direct and indirect stimulus-frequency effects in recognition.

Subsequent recognition of stimuli perceived in a given situation was studied in relation to stimulus familiarity as determined by frequency in observers' prior experience. To distinguish direct and indirect frequency effects, on the basis of selective memory retrieval and selective attention during learning, respectively, rigorous controls were imposed on stimulus rehearsability and learning co...

Allograft Nephropathy Implications for the Pathogenesis of Chronic Alloresponses in Renal Allograft Recipients: Loss of Direct and Maintenance of Indirect

Mice Alloreactivity During Allograft Rejection in Contributions of Direct and Indirect T Cell

Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice.

The immune response to transplanted allogeneic tissues is mediated by T cells that recognize donor histocompatibility Ags either via direct (donor MHC and peptides) or indirect (recipient MHC and donor-derived peptides) allorecognition pathways. The relative contribution of each of these pathways to allograft rejection remains largely unknown. To address this, we used an enzyme-linked immunospo...